Novarine is a cannabis strain providing a functionally unique cannabinoid, THCv, in a high percentage of total weight, matching or slightly exceeding the percentage of regular THC, and manifesting vastly different physiological effects.
Of equal importance, Curaleaf/Grassroots, with a presence in 23 states, has ramped up production of Novarine, turning it from a niche strain for home growers supported by online enterprises providing the seeds, to one available as regulated by each state, meeting every standard there is a regulation for, with a professionally grown, processed and inspected Whole Flower now within reach of a large and geographically diverse population.
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The information presented here is for people considering incorporating this strain into new or ongoing treatment regimens.
It cannot be expressed too strongly: extensive human trials are necessary to verify the research findings in every area in which THCv shows promise. Some of the trials may not work out, but more knowledge will be accrued no matter the outcome...but it also can't be stressed strongly enough that none of the current, and persuasive, findings have tested Whole Flower, full-spectrum, complete entourage options. So the research offers only clues as to what may prove helpful, and that is why the medical profession won't be prescribing whole flower treatments for anything. Which is why it is exciting to have personal access to Novarine from an established cannabis producer. It is up to the individual to understand what is to be consumed, and only act when an informed decision can be made. But now the individual can score his stash and trust that the genetics of the chosen strain were flourishing at the time the grow was harvested.
THCv {tetrahydrocannabivarin} has the following research documenting its capabilities:
Suppress Appetite:
https://truphys.com/therapeutic-value-of-thcv
Reverse Diabetes:
https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-020-0016-7
https://diabetesjournals.org/care/article/39/10/1777/129/Efficacy-and-Safety-of-Cannabidiol-and
Help control blood glucose and repair damage to pancreatic cells caused by diabetes:
https://pubmed.ncbi.nlm.nih.gov/27573936
Act as an anti-inflammatory, reduce arthritis pain:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931567
https://www.nature.com/articles/s41591-019-0675-0
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1476-5381.2010.00756.x
Control Blood Pressure:
https://www.marijuanadoctors.com/resources/cannabinoids/tetrahydrocannabivarin-thcv
Treat Acne:
https://pubmed.ncbi.nlm.nih.gov/27094344
Further, it has been shown to be an effective component in treatment regimens for:
Parkinson's:
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1476-5381.2011.01278.x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165958
Epilepsy:
https://www.mdpi.com/1660-4601/18/8/3993
Seizure Disorders and Schizophrenia:
https://pubchem.ncbi.nlm.nih.gov/compound/Tetrahydrocannabivarin
Intervention for Alzheimer's:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942876
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819335And, finally, it is among the ever increasing group of cannabinoids being studied for their Neuroprotective Potential:
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1476-5381.2011.01278.x
An important effort to collect enough THCv-user impressions into one database to help inform discussions of clinical interventions and provide guidelines for expectations, is being carried out by Jade Nectar in California. There are several links provided near the end of this post to the activities of this company. The Crowdsourcing Initiative can be reached can be accessed here.
This cautionary note from Dr. Peter Grinspoon should inform anyone's decision to try cannabinoids as an intervention in disease:
The most common use for medical marijuana in the United States is for pain
control. While marijuana isn’t strong enough for severe pain (for example,
post-surgical pain or a broken bone), it is quite effective for the chronic
pain that plagues millions of Americans, especially as they age. Part of its
allure is that it is clearly safer than opiates (it is impossible to overdose
on and far less addictive) and it can take the place of NSAIDs such as Advil or
Aleve, if people can’t take them due to problems with their kidneys or ulcers
or GERD.
https://www.health.harvard.edu/blog/medical-marijuana-2018011513085
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The links are mostly to Research Articles with extensive Literature Reviews replete with references. This is solid science supporting THCv as a promising subject for future research, and backing up the wide-ranging anecdotal evidence garnered due to its capacity for appetite suppression that earned the nickname The Diet Weed.
https://www.cleaneatingmag.com/clean-diet/weightloss/the-new-cbd-thcv-claims-to-be-diet-weed-but-is-it-really
https://www.healthline.com/health/substance-use/thcv#where-to-find-it
https://mashable.com/article/thcv-diet-thc
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Novarine is the first widely available commercial cannabis strain to provide THCv [or any other
cannabinoid than CBD] with a percentage weight equal to or greater than the THC
provided. Most users have never encountered such an entourage,
anchored as it is by a unique cannabinoid capable of far-ranging physiological
effects, with enough THC to play a role in pain management {and provide
what is known in the trade as a Nice Buzz, suitable for daytime
consumption, when sharp focus and getting things done are important}, as
well as providing minor cannabinoids and terpenes in the range of 3 percent of total weight.
This site is devoted solely to understanding Novarine and THCv, including the endocannabinoid system on which it acts, the receptor sites that facilitate physiological activity, and the ways in which this molecule, and the cannabis strain that provides it, can be utilized in a self-care program.
Because cannabinoids interact with the body's [internal] endocannabinoid system, replacing the naturally synthesized Anandamide and Arachidonic acid at receptor sites, they can potentially affect a profoundly important regulatory system.
"...[cannabinoids] pharmacologically
modulate CB1, CB2, GRP55, GRP119 and TRPV1 receptor activities, involving
activities such as memory, sleep, mood, appetite and motor regulation, pain
sensation, neuroinflammation, neurogenesis and apoptosis."
https://pubmed.ncbi.nlm.nih.gov/36556483
Keep that list in mind when checking out the research links. This one rogue THC-varin with a 3-carbon tail has access to all those systems and affects many of them.
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THCv is MEDICINE. Please understand the nature of the intervention you are considering and don't think you're going to score an 1/8th, roll one and hit the stratosphere because the mandated label clearly states the Total THC is near 25%. That is true but misleading at the same time, because it includes THCv in the tally with THC, instead of separately listing the percentage weight of each.
Here's the thing: THCv on its own won't get you high, except at exaggerated doses. In fact, it will most likely diminish the high through its other, non-psychotropic [bodily], effects. Novarine does provide a nice buzz, but that is only one consideration, and hardly the most important one, in deciding to utilize it as a the primary source of THCv for appetite suppression and arthritis relief -- which the blogger can state unequivocally and anecdotally is well within the purview of this strain.
Consuming too much early in the process starts the Pilgrim on the path to
habituation, in which more product is required to achieve the effects
of the early doses. Microdosing holds the
solution to this dilemma.
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Microdosing is not a new idea, and is one to consider before embarking on a treatment regime featuring daily Novarine/THCv.
The resulting effects noticeably lacked the sensation of appetite suppression, and didn't provide much of a high, either. Reasoning that, if the THCv hadn't been vaporized, it should still be intact in the remaining flower in the burn box, everything was emptied into the sieve and sifted until there was enough for one measured dose. That provided most of the normal sensation of appetite suppression, but lacked the deep muscular awareness that the intact entourage provides. These results are consistent with the idea that the presence of the entourage [all the cannabinoids and terpenes that make up a strain's unique profile] influences the effect specific molecules achieve.
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01238.x
As of the beginning of 2023, there are vape cartridges available in New York City providing full spectrum Novarine:
Hoodie 
In case you get nostalgic for the good old days of vaping:
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This cannabinoid in such quantity is something new for most cannabis consumers, even
those already enrolled in state-certified Medical Marijuana programs, and those with years of experience, certified or not. And it is certainly new to a citizenry
that could possibly benefit from one or more of its known characteristics, yet knows little to nothing -- and often believes outright
disinformation -- about getting well with cannabis.
If you decide to take Novarine for a spin, consider giving your feedback to Jade Nectar through its Crowdsourcing initiative. Yes, this molecule has an enthusiastic following, especially in areas where the seeds of some of Jade Nectar's amazing strains are distributed for free through several state licensed dispensaries.
Crowdsource Database
Jeff "Jade" Nordahl is the moving force behind the activities of Jade Nectar. In this video, he discusses mold resistance and general hardiness as traits he has selected for since the inception of his landrace preservation and dissemination project. It might be difficult to pay attention because the plant he highlights is absolutely stunning.
https://www.facebook.com/jade.nectar/videos/544965734303509
This video includes links to several more videos:
https://www.jadenectar.com/THCVgrow.html
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This interests the blogger:
THCP is a another rogue THC-varin, this one with a 7-carbon tail. It is produced along with THCv and up to 20 other named varieties of THC that decorate their ring structures in various ways but, in the end, are pharmacologically similar to THC.
This other varin turns out to be a super-THC, many times more potent than THC, with a high lasting far longer. As you might imagine, breeders and geneticists worldwide have taken an active interest in both studying and increasing the yields of this molecule. There are also varins among the lesser cannabinoids, including CBDv, that have an array of distinct effects.
THCv is always characterized as short acting, because it is assumed that all anyone is really interested in is getting high. But from the viewpoint of one who desires symptomatic relief, THCv creates long-lasting effects. The blogger fully expects a dose to last 3-4 hours, exemplifying one of the differences between Medical Marijuana and recreational use. Another is the value of avoiding habituation.
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Strains expressing THCv in significant amounts:
Jack Herer [1939-2010] was an international cannabis personality, known as the Emperor of Hemp, who had a strain crafted by Dutch genetic masters in his honor. This strain has TCHv in small but still significant amounts, and has become a part of many hybrid mixes that provide higher percentages of TCHv. Any strain currently available that has Jack in its name is descended from this original strain, and may have THCv.
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